2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Polo-like Kinase (PLK)
  5. PLK1 Isoform
  6. PLK1 Degrader

PLK1 Degrader

PLK1 Degraders (3):

Cat. No. Product Name Effect Purity
  • HY-180989
    PROTAC PLK1 Degrader-2
    		Degrader 99.48%
    PROTAC PLK1 Degrader-2 (Compound NC1) is a PLK1 PROTAC degrader with an Kd of 6.06 μM. PROTAC PLK1 Degrader-2 significantly inhibits the proliferation of HeLa cells, induces cell cycle arrest and apoptosis. PROTAC PLK1 Degrader-2 exhibits significant anti-tumor activity in a HeLa cell xenograft tumor mouse model. PROTAC PLK1 Degrader-2 can be used for the study of cervical cancer.
  • HY-181000
    PROTAC PLK1 Degrader-3
    		Degrader
    PROTAC PLK1 Degrader-3 (Compound DD-1) is a PLK1 PROTAC degrader based on the N-deglycosylation pathway, with a Kd value of 2.2 μM. The cell penetration ability of PROTAC PLK1 Degrader-3 is limited and a higher concentration is required to achieve significant degradation effects. PROTAC PLK1 Degrader-3 can be used for research on non-small cell lung cancer.
  • HY-181001
    POI ligand-4
    		Degrader
    POI ligand-4 is a PLK1 ligand and can be used for the synthesis of PROTACs, such as PROTAC PLK1 Degrader-3 (HY-181000).